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KMID : 0390320110210010227
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Chungbuk Medical Journal
2011 Volume.21 No. 1 p.227 ~ p.232
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A Case of Marchiafava-Bignami Disease in a Chronic Liver Disease Patient Who Are Not Alcoholics nor Malnourished
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Lee Hyung-Suk
Shin Dong-Ick
Beak Shin-Hye
Kim Ji-Seon
Lee Sung-Hyun
Lee Sang-Soo
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Abstract
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Marchiafava-Bignami disease (MBD), a rare complication of chronic alcoholism and pathologically characterized by symmetrical primary demyelination of the corpus callosum, is described in a non-alcoholic, not malnourished Korean male who has chronic liver disease (liver cirrhosis and liver abscess). A 61-year-old man, has liver cirrhosis and liver abscess, was admitted due to ataxia, dysmetria, minimal cognitive impairement. A brain MRI shows typical changes, high-signal intensity in corpus callosum, especially in T2 weighted images. A multiple vitamin complex was administrated and symptoms are improved. It is the first case which have occurred in non-alcoholic, not malnourished, chronic liver disease patient. In this case, we suggest that nutritional factors disturbed by impaired liver function would cause MBD.
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KEYWORD
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Marchiafava-Bignami disease, Chronic liver disease
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